This replaces my first every harmony, a 520. I had never owned one, and got a cheap deal on the 520, because I was skeptical. It was cheaply built, and died due to use (all things I knew going in), but my wife and i liked.
Well, the 650 is a damn nice remote, and I love the feel. It actually works better with the slow HR22 than the Directv remote does. I'd recommend it to anyone, looking to control up to 5 devices.